Structure of small hydrophobic protein from HMPV
3D Structure
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|---|---|
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Functional Information
The hMPV SH protein has been reported to regulate host immune responses. Viroporin that forms a ion channel probably displaying low ion selectivity (PubMed:24672047). Plays a role in counteracting host innate immunity by inhibiting TLR7/MyD88/TRAF6 signaling and STAT1 phosphorylation, leading to down-regulation of type-I IFN (PubMed:27131212, PubMed:29789500).
- Membrane permeability: : HMPV SH expression can increase permeability to hygromycin B.
- Membrane fusion:HMPV SH can decrease HMPV F protein-promoted membrane fusion activity.
- Immunopathogenesis:: HMPV SH is thought to be important in immunopathogenesis.
- Type I IFN signaling:HMPV SH downregulates type I IFN signaling through the targeting of STAT1.
Interactions
- Interacts with glycoprotein G.
Post-Translational Modification
- N-linked glycosylation at Asn76, Asn121 and Asn149.