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Structure of G glycoprotein from HMPV

3D Structure

PDB ID Method Length Downloads
6U5O Cryo-EM 1-294 Click here
8FPJ Cryo-EM 1-294 Click here
8PDP Cryo-EM 288-294 Click here
8PDQ Cryo-EM 288-294 Click here
8PDR Cryo-EM 288-294 Click here
8PDS Cryo-EM 288-294 Click here

Functional Information

Plays critical roles in regulating RNA replication and transcription through its interactions with multiple proteins (By similarity). Tethers the RNA-directed RNA polymerase L to the nucleoprotein-RNA complex (PubMed:31698413). Recruits the M2-1 protein, a processivity factor that is required for efficient transcription of viral RNA (By similarity). Acts as a chaperone for neo-synthesized nucleoprotein by forming an N-P complex that preserves N in a monomeric and RNA-free state and prevents the association of nascent N with host cell RNAs (By similarity). Recruits the host phosphatase PP1 to inclusion bodies to regulate viral transcription (By similarity).

Interactions

  • Interacts with protein M2-1; the interaction between the two tetramers is required for the anti-termination and elongation transcriptional activities of protein M2-1 (By similarity).
  • Interacts with host phosphatase PP1; this interaction recruits PP1 to the inclusion bodies (By similarity).
  • Formation of a complex PP1/M2-1/P allows P to target host PP1 phosphatase to the M2-1 substrate (By similarity).
  • Interacts with the nucleoprotein N; the phosphorylated phosphoprotein P binds to N-RNA complex. Interacts with the monomeric RNA-free nucleoprotein N (By similarity).
  • Interacts with RNA-directed RNA polymerase L (via N-terminus); the association of P and L forms the polymerase complex (PubMed:31698413).

Domains Orgainzation

  • Regjon
  • Compositional bias
  • Region
  • Region
  • Region
  • Region
  • Region
  • Region
  • Compositional bias
  • Region
12-28 97-120 97-136 123-128 135-157 169-194 251-279 260-294 267-282 281-294
Binding to monomeric RNA-free nucleoprotein1 publication Basic and acidic residuesautomatic annotation Disorderedautomatic annotation Binding to host phosphatase PP1By similarity Binding to protein M2-1By similarity Oligomerization and binding to RNA-directed RNA polymerase L1 publication Binding to RNA-directed RNA polymerase LBy similarity Disorderedautomatic annotation Acidic residuesautomatic annotation Binding to the N-RNA complex